Jalview

Jalview bridges the gap between sequence and structure by associating alignments with 3D molecular models. This feature allows you to map sequence conservation, variations, and annotations onto protein or nucleic acid structures, providing profound structural insights. You can load structures from the PDB database and visualize how alignment columns correspond to structural features like active sites or binding regions. This direct linkage is crucial for understanding structure-function relationships in molecular biology and bioinformatics projects.